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Single large dose of liposomal amphotericin B effective for histoplasmosis in AIDS

Researchers in Brazil, led by Alessandro Pasqualotto, have shown that a 10mg/Kg single dose of liposomal amphotericin B, followed by itraconazole is at least as effective as daily liposomal amphotericin B. Clinical centres in Brazil screend 882 adult patients with HIV infection for disseminated histoplasmosis. From this sample population they randomised 118 people to be […]

FDA approves new treatment for invasive candidiasis

Cidara Therapeutics and Melinta Therapeutics have announced that the U.S. FDA have approved Rezzayo™ (rezafungin for injection). This new medication is for the treatment and prevention of candidemia and invasive candidiasis in adults who have limited or no alternative treatment options. Rezzayo is a once-weekly injection that in clinical trials, proved to be non-inferior to […]

LIFE Worldwide launches revamped fungal microscopy course

LIFE Worldwide, in collaboration with the Fungal Infection Trust and the University of Manchester, is pleased to announce the re-launch of its popular fungal microscopy course –  This new site has updated content, improved navigation, and more visual resources added to modules 1 and 2, with further work planned to overhaul modules 3 and […]

Impact of hurricane activity on invasive mould infections (IMI)

In August 2017, hurricane Harvey devastated the Houston metropolitan area and adjacent counties. Much of the post-hurricane clean-up was carried out by members of the public, with little or no personal protective equipment. As the damage was mostly caused by flooding, the public were exposed to greater levels of mould, due to these damp conditions, […]

How to minimise risk of mucormycosis in hospital linens

Healthcare linens (HCLs) have often been thought to contain Mucorales spores, which present a health hazard for those with compromised immune systems. Mucorales are widely distributed in the environment, including in soil, vegetation and compost, and spores are easily aerosolised and dispersed, so healthcare providers need to remain vigilant to ensure that these pathogens are […]

Length of treatment regime in chronic pulmonary aspergillosis (CPA)

One of the key questions when treating CPA is optimal length of drug regimens. New research is challenging established views of treatment length. CPA is an uncommon and problematic pulmonary disease, complicating many other respiratory disorders, thought to affect over three million people globally. The most common form of CPA is chronic cavitary pulmonary aspergillosis […]

Histoplasmosis in Guatemala – the danger of under-estimating fungal infections

Histoplasmosis is recognised as a major complication in those with HIV, even when receiving anti-retroviral treatment, but exact rates for this infection have been unclear.  A new study carried out by Narda Medina and colleagues has shown that histoplasmosis is more prevalent than originally thought. Their screening programme in Guatemala demonstrated overall histoplasmosis incidence in […]

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