A newly published study by Sturny-Leclère et al. (2025) examines the outcomes of people living with HIV with disseminated histoplasmosis (DH) undergoing treatment with liposomal amphotericin B (L-AmB). The researchers quantified Histoplasma from blood samples collected during a clinical trial in Brazil. The trial compared three L-AmB treatment regimens in 105 HIV-positive patients diagnosed with […]
Rising threat of fungal infections in intravenous drug users
A new comprehensive review published in Open Forum Infectious Diseases warns of a growing public health concern: a sharp rise in severe fungal infections among people who use drugs, especially those who inject them. The review, led by Dr Jose Portugal Gonzales and Dr Luis Ostrosky-Zeichner of the University of Texas Health Science Center at […]
WHO publishes report on fungal diagnostics and antifungal treatments
The World Health Organization (WHO) today published its first-ever reports addressing the critical lack of medicines and diagnostic tools for invasive fungal diseases, showing the urgent need for innovative research and development (R&D) to close these gaps. Fungal diseases are an increasing public health concern, with common infections – such as Candida, which causes oral and vaginal thrush – growing increasingly […]
New global guideline for candidiasis
The new Global Guideline for the Diagnosis and Management of Candidiasis (Cornely et al., 2025) is a comprehensive review and update on the diagnosis, treatment, and prevention of Candida infections, developed by the European Confederation for Medical Mycology (ECMM) in collaboration with ISHAM and ASM. Candida species, particularly Candida auris and fluconazole-resistant Candida parapsilosis, pose […]
Invasive pulmonary aspergillosis in interstitial lung disease
A recent study published in BMC Pulmonary Medicine has shed light on the clinical features and risk factors associated with invasive pulmonary aspergillosis (IPA) in patients suffering from interstitial lung disease (ILD). Most ILD patients are not immunocompromised and yet affected by IPA, as in other conditions compromising lung function. The main finding was a […]
Increased risk of fungal infections in multi-drug-resistant tuberculosis patients in Indonesia
A recent study published in the Journal of Fungi reveals that patients with multi-drug-resistant tuberculosis (MDR-TB) in Indonesia are at a significantly higher risk of co-infections with chronic pulmonary aspergillosis (CPA) and chronic pulmonary histoplasmosis (CPH). This is the first research into the incidence of CPA as a co-infection of MDR-TB patients in Indonesia in […]
New study highlights disparities in outcomes of pleural infections
A new study, conducted at Changhua Christian Hospital in Taiwan, has shed light on the varied outcomes of bacterial, tuberculous, and fungal pleural infections (empyema), a potentially life-threatening condition. Published in The International Journal of Tuberculosis and Lung Disease, the research emphasises the urgent need for tailored treatment approaches. Empyema occurs when infected fluid accumulates […]
Invasive Fungal Infections in ANCA-Associated Vasculitis
A new case-based review published in Clinical Rheumatology highlights the precarious situation faced by patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV) when complicated by invasive fungal infections (IFIs). The review, authored by Dr. Sahana Baliga and colleagues from the PD Hinduja National Hospital and Medical Research Centre, underscores the high mortality and diagnostic difficulties associated […]
Azole-resistant Aspergillus fumigatus found on hospital equipment
Conditions caused by Aspergillus fumigatus are becoming more prevalent across the globe. This is of particular concern to the immunocompromised, and those in intensive care unit (ICU) who are admitted for prolonged periods and treated with immunosuppressive agents. Invasive aspergillosis caused by A. fumigatus is becoming more difficult to treat, as it becomes resistant to […]
Persistent lung defects after recovery from PCP in AIDS
Pneumocystis jirovecii pneumonia (PCP) is one of the most frequent infections seen in people with HIV. Before antiretroviral therapy (ART) became commonplace, mortality from PCP was exceptionally high if it led to respiratory failure, with an in-hospital mortality of 80%. With the advent of ART, in-hospital mortality rates have improved to around 10%. This new […]